Bacterial wilt, caused by Ralstonia solanacearum (Yabuuchi, et al., 1995) race 3 (R3bv2A), is an important disease contributing to low potato yields in temperate areas and tropical highlands. In Kenya, the disease is widespread in most potato growing areas causing yield losses of between 50 and 100%. This disease has no known cure; the chemicals are ineffective and expensive, the biological control agents are ineffective, the phytosanitary methods are either expensive or difficult to apply, and the cultural methods are largely impractical. Host resistance could be the best option for controlling the disease, but none of the currently grown potato cultivars in the country are resistant. Recent research efforts by CIP scientists have led to identification of potato clones with resistance to R3bv2A. There is need to introgress this resistance into the more popular Kenyan potato cultivars so as to increase potato production in Kenya. The specific objectives of this study are therefore: (1) to determine the distribution of R3bv2A in the potato growing areas in Kenya, (2) to establish farmers’ perceptions and knowledge on bacterial wilt and other key potato production constraints, (3) to evaluate the Kenyan potato germplasm, CIP advanced clones and their hybrids for resistance to R3bv2A, and (4) to determine the gene actions involved in the resistance of potatoes to R3bv2A. These objectives will be achieved between 2012 and 2014 in Kenya. A breeder-farmer participatory rural appraisal (PRA) will be carried out in major potato growing parts of the country to gather information on spread of bacterial wilt, farmers’ views on bacterial wilt, and other key potato production constraints. Selected potato varieties from Kenya and the more bacterial wilt-resistant CIP lines will be screened for resistance. Selected parents, based on resistance to bacterial wilt and yield, will be crossed in a full diallel mating scheme and the resultant F1 single cross hybrids crossed gain to give F1 double cross hybrids. The F1 double cross hybrids will be evaluated for their resistance to bacterial wilt in multi-location trials in disease hotspots in Kenyan highlands. General and specific combining abilities of the lines and maternal effects for bacterial wilt will be determined to give an idea on gene action. The expected research outputs include potato genotypes with high resistance to bacterial wilt that can be developed into cultivars, PhD thesis and publications.